Non-surgical Procedures

Rejuran vs. dermal fillers: What are the differences?


Rejuran and dermal fillers are two options for treating skin that maintain a lot of similarities. 

When it comes to professional skin treatments, there seems to be a never-ending range of choices to pick from. Each option offers rejuvenating benefits to areas of concern like uneven skin tone or ageing skin, making it difficult to distinguish the differences between treatments and which is best for your skin.

Both options offer unique treatment methods and benefits that can divert interest between the two. Knowing the differences between Rejuran and dermal fillers can help you choose which option will provide the most suitable skin rejuvenation for you.

What is Rejuran?

Rejuran is a groundbreaking addition to injectable treatments for skin rejuvenation. The injections focus on promoting skin healing, skin elasticity, and the reduced appearance of fine lines and wrinkles.

It successfully does so through the inclusion of Polynucleotides, which are gathered from salmon DNA. This ingredient, along with others that nurture skin hydration and repair, stimulates collagen production to leave you with more radiant skin.

It is a non-invasive treatment for skin laxity as it is inserted into the dermis layer of the skin through microinjections. There, the Polynucleotide stimulates fibroblasts, providing collagen stimulation that improves thinner skin and increases its elasticity.

How does Rejuran work?

The DNA fragments gathered from salmon, otherwise known as Sodium DNA, are used for stimulating collagen production in the skin. It is common for ageing skin to experience a decrease in collagen synthesis as the years go by. Thus, Polynucleotides allow many to continue maintaining skin elasticity past the expected age of decline.

Polynucleotide, when injected into the skin, also offers the benefit of activating anti-inflammatory responses. This promotes wound healing and generally improves overall skin quality. While restoring collagen in the face leads to improved skin texture and fewer fine lines and wrinkles, it is this boosted healing factor that prevents concerns like acne scars and lasting blemishes.

What are dermal fillers?

Dermal fillers are an injectable treatment that focuses on skin concerns such as deep wrinkles, skin laxity, and sunken features. It is available as a temporary injectable, shaping the face by replenishing lost volume and reducing creases in the skin texture.

The injectable used for a dermal filler can vary depending on the length of time desired for effects, and the skin concern to be addressed. However, hyaluronic acid dermal fillers are the most common type of temporary filler. It can be reversed through the appropriate application of the enzyme hyaluronidase. Hyaluronic acid in these forms are also known as injectable moisturisers due to its volumising and positive effect on skin hydration.

The most common places to inject dermal filler include:

It can even be used to improve skin texture and signs of ageing on the back of the hands. Making it a versatile treatment option for those interested in non-invasive yet effective injectables.

How do dermal fillers work?

Traditional dermal fillers do not follow the pattern of other skin injectables of smoothing wrinkles and improving skin quality. Rather, it focuses on restoring facial volume, which leads to the expected benefits of skin rejuvenation and even skin texture.

The commonly used hyaluronic acid fillers work by injecting the substance into the targeted area to promote volume. The hyaluronic acid chains are cross-linked to create a gel-like consistency that offers this volume. The amount of cross-linking is what determines both the gel’s firmness and longevity.

Thicker fillers have more cross-linking and are generally placed deeper within the face or in areas that require more structure. Meanwhile, thinner fillers have less cross-linking to provide a softer and smoother effect. This finer filler is also injected in areas of the face which require a softer feel.

By adding volume to the face in key areas, fillers can smooth transitions between adjacent areas of the face or emphasise certain features. For example, dermal filler can be injected to straighten the jawline by adding volume around the jowl and chin. The recent addition of bio-remodelling injections to the injectables market can also stimulate collagen production to rejuvenate the skin. 

What is the difference between Rejuran and dermal fillers?

Injectables have maintained a consistent popularity due to their versatility and impact on promoting collagen synthesis. Both Rejuran and dermal fillers are key examples of injectable popularity, but only the former works in boosting natural collagen production and improving specific skin concerns. Fillers, in contrast, solely focus on improving the appearance of facial structure through subtle volumising.

However, these methods offer additional unique differences beyond their effects or lack thereof on collagen. Whether that is their chemical makeup, how they work once injected into the skin, or their results. Understanding the differences between Rejuran and dermal fillers can allow you to choose which option you prefer or what works best for your particular skin concerns.


Rejuran is constructed to steadily improve skin elasticity in a manner that makes it last for more than a year, by increasing the collagen produced in the skin. As Rejuran encourages the skin to produce collagen, the results are gradual and cumulative over time with follow-up treatments, without becoming overfilled.

In contrast, the dermal volume offered by fillers can generate results which can be seen immediately, but the commonly used hyaluronic acid means these effects are temporary. Once injected, the desired effect of the filler usually lasts between 6-12 months, but MRI scans have revealed that filler can remain within the skin for many years, so a minimalist approach should be taken to avoid overfilling. The exact length of time depends on the strength of the filler, its consistency, and the frequency of follow-up treatments. 

Method of improvement

How Rejuran and dermal fillers improve your skin’s appearance greatly differs, despite both being injectable forms of skin treatment. Rejuran treatment is focused on gradual and long-lasting results, which is why it works to improve the skin’s regenerative processes. By targeting skin repair and boosting collagen production, Rejuran improves dull skin and laxity, leaving behind a more radiant complexion.

Meanwhile, dermal fillers are injected to attract and retain water in the skin, providing more volume through the hyaluronic acid’s cross-linking. It is a targeted means of improvement, the eventual formation of firm gel creating a plumping effect at the site of injection.

Targeted skin conditions

Fine lines and wrinkles are both areas of concern that can be improved by the efforts of either Rejuran or dermal fillers. However, beyond this condition, both treatments focus on differing skin improvements.

Rejuran is a tool of versatility, working to smooth out skin texture and reducing the appearance of blemishes and scars. That is why it can be used to improve acne scars or reduce the appearance of enlarged pores. Rejuran also contains a form of hyaluronic acid, offering increased skin hydration with each injection. This prevents skin dryness as well as improves collagen and elastin production.

The volumising effect of fillers contours the face and builds out areas that may have experienced a decrease in volume from weight loss or ageing. It does not work as a skin booster, but rather a means of filling out the face as needed.

Injection sites

Rejuran injections do not have a specific area of insertion. This is because the treatment is not used to target key facial features, but rather works as a full face treatment or for the neck.

Alternatively, the injection sites of dermal fillers must be carefully chosen. This is because fillers are used to add volume to key areas of the face. Common injection sites include the cheeks, lips, or chin.

Why choose Rejuran over dermal fillers?

When deciding between Rejuran and dermal fillers, it is best to consider your own skin concerns and desired results. Consulting with a trusted medical practitioner can help you determine which option works best with your skin type and will provide optimal results.

Regardless, Rejuran is suitable for improving overall skin health for various reasons:


Although fillers offer noticeable results, they do not have the same versatility as Rejuran. Fillers typically are used to target several areas of the face, adding volume as needed and smoothing out the edges of facial contours. While this has the added benefit of reducing the appearance of fine lines and wrinkles, it does not target skin texture and induce collagen stimulation like Rejuran.

For those who have multiple concerns about their skin, Rejuran is the more logical option of the two. It provides a holistic approach to restoring skin health, improving its quality over time across multiple areas of concern.

Holistic treatment

While dermal filler ooperate by filling in lines and wrinkles, Rejuran deviates by taking a holistic approach. The treatment supports the skin’s natural regenerative abilities by promoting collagen production and the renewal of healthy skin cells. This approach means a gradual and sustainable improvement in skin condition is possible, especially when follow-up appointments are maintained to continue supporting the skin’s healing and regenerative abilities. 

Rejuran vs. dermal fillers: How to choose the right treatment

Choosing the right option between Rejuran and dermal fillers comes down to what you are most comfortable with, and what kind of results you are after.

It is recommended to choose Rejuran if you are looking for:

  • Collagen stimulation without being overfilled
  • Versatility and improvement of multiple skin concerns
  • Skin hydration
  • Reduction in the appearance of enlarged pores
  • Improvement of acne scars and other distinctive skin blemishes
  • Improved skin healing
  • Smoother skin tone and texture
  • A more holistic approach

Dermal fillers may be the choice of treatment for you if you want to:

  • Replenish lost facial volume
  • Smooth out the signs of ageing
  • Shape or contour the face
  • Immediate results
  • Improve facial symmetry

Considering the benefits of both procedures can help you decide which option is best for you. It should be noted that it is possible to combine skin treatments for optimal improvement of your skin. Fillers and Rejuran injections can be used together with careful planning. Namely, to boost collagen stimulation and skin rejuvenation. This reduces the appearance of static wrinkles and contours the face with targeted volume insertions.

Book a consultation with a practitioner at Victorian Cosmetic Institute to create a personalised treatment plan to treat your core skincare concerns.

Where to get Rejuran and dermal fillers in Melbourne?

The delicate application of Rejuran and dermal fillers requires a team of experienced practitioners dedicated to their patients. At Victorian Cosmetic Institute, we prioritise the well-being of all our patients, and provide you with realistic expectations on what can be achieved..

Whether you choose Rejuran, dermal fillers, or a combination of both treatments, our practitioners are always ready to tailor a treatment plan for you. 

Simply book online or phone our friendly Customer Care team on 1300 863 824 to enquire about your consultation options.