Rejuran

Last updated December 2023

What is Rejuran treatment?

Rejuran is the brand name for a popular treatment that contains Polynucleotides, which are DNA fragments derived from salmon. These Polynucleotides promote skin regeneration, improve elasticity, and reduce the appearance of fine lines and wrinkles when injected into the skin. Rejuran injections are often used as part of anti-aging and skin rejuvenation procedures, especially when there will be benefit from additional collagen stimulation in the upper layers of the skin.

Launched in Korea in 2014, Rejuran was exclusively used in Asian countries such as Korea and Singapore, before being approved in Australia in July 2023.

What is in Rejuran?

Rejuran is an injectable product containing Polynucleotides from wild salmon, otherwise known as Sodium DNA. These polynucleotides are short DNA fragments, typically sourced from salmon DNA or other marine organisms. When injected into the skin, they are believed to offer several benefits for skin health and appearance. 

Rejuran is injected into the dermis layer of the skin using micro injections to stimulate the fibroblasts to produce collagen.

Is Rejuran the same as dermal filler?

Rejuran is an injectable Polynucleotide which stimulates collagen production in the skin. It is very different from dermal fillers which provide volume and fullness.

Unlike dermal fillers that focus on providing volume, Rejuran’s Polynucleotide is specifically formulated to target the stimulation of collagen within the superficial or upper layers of the skin. While dermal fillers enhance facial fullness, Rejuran aims to promote natural collagen production, contributing to skin rejuvenation and a more youthful appearance by addressing visible signs of ageing.

Where can Rejuran injections be used?

There are several different formulations of Rejuran available. We use both Rejuran and Rejuran I.

Rather than targeting specific areas such as cheeks, temples or the forehead, Rejuran is best used as a full face treatment. Rejuran is also ideal to be used for treatment of the neck. 

Rejuran I is specifically formulated to be used around the under eye area, promoting collagen and addressing fine lines and signs of skin ageing.

What does Rejuran treatment involve?

Patients are requested to arrive at their appointment free of makeup, moisturiser and sunscreen. Upon arrival, patients are prepared for treatment by having pre-treatment photographs taken and a VISIA skin scan is performed to measure the skin’s health and condition. An anaesthetic cream is then applied to the treatment area to make the treatment as comfortable as possible. 

Rejuran is administered by the practitioner to the treatment area using micro injections to ensure even distribution within the upper layers of the skin. 

Once the treatment has been completed, we request patients book a follow up appointment in 2 to 4 weeks for further photographs and review.

What are the risks and side effects of Rejuran injections?

Rejuran injections, like all medical procedures, come with potential risks and side effects. It’s essential to be aware of these considerations before opting for the treatment. Here’s an overview of the associated risks and side effects, as well as guidelines on what to avoid after Rejuran injections.

The risks and side effects associated with Rejuran injections include:

• Lumps or bumps: In most cases, patients develop small lumps or bumps under the skin at the injections site which look like tiny mosquito bites. These usually subside within 24 hours.
• Bruising and swelling:  Mild swelling is common, typically resolving within a few days. Whilst we take precautions to avoid bruising, such as using the Accuvein to visualise veins to avoid bruising, it may still occur. If bruising occurs it typically subsides within a few days.
• Infection: While rare, there is a minimal risk of infection at the injection sites. Following proper aftercare instructions, refraining from using skin care for 24 hours following treatment and not touching the treated area can help mitigate this risk.
• Allergic reactions: Although uncommon, allergic reactions to components of Rejuran can occur. It’s crucial to inform the practitioner of any known allergies beforehand.
• Discomfort: Mild discomfort during or after the treatment is possible. It’s advisable to communicate any persistent, severe or escalating pain to your practitioner.

What to avoid after Rejuran  

• Excessive sun exposure: Protect the treated areas from prolonged sun exposure to reduce the risk of pigmentation changes. Use sunscreen with high SPF.
• Intense physical activity: Avoid strenuous exercise or activities that may increase blood flow to the treated areas immediately after the procedure.
• Harsh skin care products: Refrain from using harsh or abrasive skin care products on the treated skin, and follow the recommended post-treatment skin care routine provided by your practitioner.

Can I have Rejuran treatment if I have a seafood allergy?

FAQs

Are Rejuran injections painful?

Topical anaesthetic cream is applied prior to treatment to numb the area to be treated. Following treatment there may be a little temporary discomfort around the injection sites as the anaesthetic cream wears off.

How long do the results last?

Results can vary from person to person, and factors such as individual skin characteristics, lifestyle, and the specific concerns being addressed can influence the longevity of the effects. However, upon attending their review appointment, many patients report noticing an improvement in their skin quality within weeks. 

The collagen stimulation initiated by Rejuran tends to have a gradual and cumulative effect, with optimal results becoming noticeable after a series of sessions.

Depending on the patients age, skin quality and general health, a course of 3 treatments 2 to 3 weeks apart may be recommended. Followed by a treatment every 6-12 months to nurture a healthy skin condition.

Can I combine Rejuran injections with other treatments?

Yes, Rejuran injections can be combined with other treatments, and the decision to do so depends on an individual’s specific goals and the advice of their practitioner. Combining treatments can offer comprehensive and synergistic benefits. Here are some common combinations:

• Anti-wrinkle injections: Combining Rejuran with anti-wrinkle injections is a common approach. While Rejuran works on skin texture and collagen, anti-wrinkle injections target dynamic wrinkles by temporarily relaxing facial muscles.
• Chemical peels: Chemical peels can enhance the exfoliation process and improve the absorption of Rejuran. This treatment combination should be performed a few weeks apart and can be beneficial for addressing uneven skin tone and texture.
• Tixel: Tixel and Rejuran complement each other well. Tixel uses heat to create micro-injuries, stimulating collagen, while Rejuran provides additional support for collagen production and skin rejuvenation.
• IPL treatment: Intense pulsed light (IPL), may be combined with Rejuran to address specific skin concerns such as pigmentation irregularities and sun damage.

How much do Rejuran injections cost?

Rejuran injections are priced per syringe. The price for Rejuran injections can be found on our pricing page.

Is Rejuran the same as anti wrinkle injections?

Rejuran and anti-wrinkle injections are two very different treatments. Rejuran stimulates fibroblasts to produce collagen to improve skin texture, reduce fine lines and skin rejuvenation. 

Anti-wrinkle injections temporarily relax muscles to prevent dynamic lines, especially in areas where muscle activity contributes to lines and wrinkles such as forehead, crows feet and frown lines.

How many Rejuran treatments will I need?

The number of Rejuran treatments needed can vary based on individual factors such as the specific skin concerns being addressed, the extent of those concerns, and the desired outcomes. Generally, Rejuran treatments are performed in a series of 3 sessions, spaced 2 to 3 weeks apart, to achieve optimal results.

It’s crucial to follow the guidance of the practitioner providing the treatments and to communicate your goals and expectations during the consultation.

How long until I see results from Rejuran injections?

Generally, it is common for individuals to notice gradual improvements in skin texture and firmness after the first few weeks following Rejuran treatments. However, for optimal and long-lasting results, it’s essential to complete the recommended series of sessions and adhere to any post-treatment care instructions provided by your healthcare professional.

What is the downtime for Rejuran treatment?

The downtime for Rejuran treatment is typically minimal, and many individuals are able to resume their normal activities shortly after the procedure.

Due to there being micro-injection points there may be some minor redness and visible bumps. These usually subside within 24 to 48hrs.

Although rare, there may be some bruising due the puncturing of the skin.

However, the exact duration of downtime can vary among individuals, and it is influenced by factors such as individual skin sensitivity, the specific technique used, and any additional treatments performed simultaneously.