How long should someone be on Kligmans?
If they are getting an irritation is it likely to be the tretinoin?
Is there a protocol for reducing its application when the desired result is achieved?
When first using Kligmans, usage is built up slowly; for example. first two weeks, use one day only, second two weeks, two days only, and so on until usage is built up to every evening.
If irritation occurs, just back the usage down, for example, if you built up to using it 3 times a week and started to be irritated, go back down to 2 again, until you can once again slowly build it up.
We find that it can be used for a long time without break. Coming off it should be gradual, so rebound pigmentation does not occur (in a reverse manner to above suggestion for example).